Types of antidepressants
Some medications used to treat depression include:
Selective serotonin reuptake inhibitors (SSRIs)
SSRIs work by blocking the reuptake of serotonin. This increases levels of serotonin in the brain.
Serotonin is a neurotransmitter that can have an impact on lots of different bodily functions and systems. These include sleep, digestion and memory. Serotonin is also widely known as being one of the brain’s ‘happy chemicals’, because it appears to be able to influence mood and how we process emotions.
Research shows that high levels of serotonin in the brain are linked to elevated mood and feeling happy. On the other hand, low levels of serotonin are linked to the symptoms of depression, including feeling sad, upset and generally low in mood.
Therefore, SSRIs can improve a person’s mood by increasing the levels of serotonin in their brain.
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
SNRIs work in a similar way to SSRIs, by blocking the reuptake of neurotransmitters that are linked to mood. In the case of SNRIs, the focus is on the neurotransmitters norepinephrine and serotonin. Increasing the levels of these chemicals in the brain can improve mood and reduce depression symptoms.
Tricyclic antidepressants (TCAs)
TCAs are an older type of antidepressant that also help to increase levels of serotonin and norepinephrine in the brain. They are not usually prescribed as a first line of treatment for depression because they can cause some unpleasant side effects. They are also more dangerous in the event of an overdose.
However, they might be prescribed to someone who has not responded to other antidepressants. They may also be recommended for other conditions, such as OCD and bipolar disorder.
Monoamine oxidase inhibitors (MAOIs)
MAOIs work by blocking the enzyme that breaks down neurotransmitters in the brain. This helps to increase the levels of neurotransmitters, such as serotonin, which can improve mood. However, people who take MAOIs have to have a strict diet because this medication can be dangerous when interacting with certain foods. Therefore, they only tend to be prescribed to people with treatment-resistant depression.